Other substances

Verteporfin

A benzoporphyrin derivative.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Verteporfin is a benzoporphyrin derivative used as a photosensitizer in the photodynamic therapy of wet-form macular degeneration (DrugBank).


Verteporfin on PubChem
Verteporfin on Wikipedia

Synonyms

Verteporphin

Marketed as

VISUDINE

 

Structure image - Verteporfin

CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C

Supporting references

Link Tested on Impact factor Notes Publication date
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2
Biophysical assay Animal model In vitro 		In vitro biophysical assay; in vitro binding assay; Vero E6 cells; HEK293T cells; BALB/c mice; SARS-CoV-2 (S protein) pseudovirus; SARS-CoV-2 strain nCoV-SH01 (GenBank: MT121215.1) 9.51

Eliminates SARS-CoV-2 infection-induced cytopathic effect and N protein expression in Vero E6 cells at 0.31 μM. The compound was estimated to have EC50 of 0.03 μM and selectivity index of 368.93 (1.35 μM and 224.61 for remdesivir, respectively). Pre-treatment of cells by 1.25 μM solution completely prevented SARS-CoV-2 infection and treatment after infection resulted in 95.4% decrease in viral RNA replication. The drug binds human ACE2 in vitro. It reduces viral loads, pulmonary tissue damage and outer signs of infection in hACE2-expressing mice.

 Dec/09/2020
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction
Small molecule In vitro 		in vitro binding assay; HEK 293T cells; Vero E6 cells; Calu-3 cells 10.16

Disrupted ACE2-RBD (of SARS-CoV-2 spike protein) interaction and inhibited RBD binding to ACE2 on cell surface in vitro in dose-dependent manners. Inhibited pseudotyped- and live virus entry into cells.

 Nov/18/2020

AI-suggested references

Link Publication date
Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins.
May/14/2021
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