Other substances

X-206

A polyether ionophore antibiotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

X-206 is a polyether ionophore antibiotic isolated from actinomycetes. It displays potent anti-malarial activity (Otoguro et al., 2001).

X-206 on PubChem

 

Structure image - X-206

CC[C@H]1[C@](CC[C@@H](O1)[C@@]2(C[C@H]([C@@](O2)([C@@]3(CC[C@H](O3)[C@H]([C@]4([C@@H](C[C@@H]([C@H](O4)C[C@@]5([C@H](CC[C@@H](O5)[C@@H](C)[C@@H](C[C@H]6CC[C@@H]([C@H](O6)[C@@H](C)C(=O)O)C)O)C)O)C)C)O)O)C)O)C)C)(C)O

Supporting references

Link Tested on Impact factor Notes Publication date
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro
Small molecule In vitro 		Vero E6 cells; Vero E6-hTMPRSS2 cells; Calu-3 cells 4.10

Inhibited SARS-CoV-2 in cell culture with high selectivity (the ratio between IC50 and EC50). It also supressed SARS-CoV-2 expression at the levels of both RNA and protein and reducess the production of infectious viral particles. It was experimentally most effective in suppressing SARS-CoV-2 expression, when the host cells were treated 0.5 hours pre- or 2 hours post-infection.

 Nov/25/2020
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