Withanone
A plant steroidal lactone.
General information
Withanone is a bioactive plant steroidal lactone used in traditional Indian medicine (Vaishnavi et al., 2012).
Withanone on PubChem
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Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
Spike protein ACE2 Animal model In vitro In silico |
in silico; in vitro binding assay; humanized Zebrafish (carrying A549 cell xenotransplants) | 3.22 | The compound inhibited the interaction between SARS-CoV-2 Spike protein RBD and the host ACE2 receptor in a dose-dependent manner with an IC50 of 0.33 ng/mL in vitro. |
Mar/11/2021 |
|
Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
TMPRSS2 In vitro In silico |
in silico; MCF7 cells | 3.22 | Predicted to inhibit the host TMPRSS2 protease. It was also shown to downregulate the protease in vitro. |
Jun/16/2020 |
