Other substances

WiNeWsE

A plant extract.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

WiNeWsE is a Withania somnifera leaf 80% ethanol extract formulation enriched in withanone. It reduced SARS-CoV-2-induced pathology in a humanized zebrafish model (Balkrishna et al., 2021).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
Spike protein ACE2 Animal model In vitro In silico 		in silico; in vitro binding assay; humanized Zebrafish (carrying A549 cell xenotransplants) 3.22

The extract reduced SARS-CoV-2-induced pathology in a humanized zebrafish model.

 Mar/11/2021
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