Vitamin B12

A water-soluble vitamin.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Natural product

Supporting references
Contradictory references
AI-suggested references
Clinical trials

General information

Cyanocobalamin (vitamin B12) is a natural water-soluble compound produced by intestinal microbes necessary for proper neural metabolism, haematopoiesis, metabolism of macromolecules and energy storing molecules. Vitamin B12 deficiency causes neurologic or anaemia disorders (NCIt).

Vitamin B12 on DrugBank
Vitamin B12 on PubChem
Vitamin B12 on Wikipedia




Structure image - Vitamin B12


Supporting references

Link Tested on Impact factor Notes Publication date
A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients.
Preprint Cohort study

used as vitamin D3 1000 IU OD, magnesium 150mg OD and vitamin B12 500mcg OD upon admission when not requiring oxygen therapy

Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 virus
RdRpol Small molecule In silico
in silico 3.24

Predicted to bind the SARS-CoV-2 RNA-dependent RNA polymerase active site.


AI-suggested references

Clinical trials

ID Title Status Phase Start date Completion date
NCT04407572 Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women Completed Apr/20/2020 Jun/14/2020
  • Alternative id - zinc-dvit-covid19
  • Interventions - Other: Serum zinc, vitamin d vitamin b12 levels .
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Pinar Yalcin Bahat, Istanbul, İ̇stanbul, Turkey
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 44
  • Age - 18 Years to 45 Years   (Adult)
  • Outcome measures - Serum zinc, vitamin d vitamin b12 deficiency levels
NCT04395768 International ALLIANCE Study of Therapies to Prevent Progression of COVID-19 Recruiting Phase 2 Sep/09/2020 Dec/31/2021
  • Alternative id - Alliance-COVID19
  • Interventions - Dietary Supplement: Vitamin C|Drug: Hydroxychloroquine|Drug: Azithromycin|Dietary Supplement: Zinc Citrate|Dietary Supplement: Vitamin D3|Dietary Supplement: Vitamin B12
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - National Institute of Integrative Medicine, Melbourne, Victoria, Australia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Symptoms|Length of hospital stay|invasive mechanical ventilation or mortality|Mortality|mechanical ventilation|oxygen|ICU|days in hospital|days in ICU|renal replacement therapy|Extracorporeal support