Other substances

Vitamin B12

A water-soluble vitamin.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Cyanocobalamin (vitamin B12) is a natural water-soluble compound produced by intestinal microbes necessary for proper neural metabolism, haematopoiesis, metabolism of macromolecules and energy storing molecules. Vitamin B12 deficiency causes neurologic or anaemia disorders (NCIt).

Vitamin B12 on DrugBank
Vitamin B12 on PubChem
Vitamin B12 on Wikipedia

Synonyms

Cyanocobalamin

FDJOLVPMNUYSCM-WZHZPDAFSA-L (InChl Key)

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients. Preprint Cohort study	Patients		used as vitamin D3 1000 IU OD, magnesium 150mg OD and vitamin B12 500mcg OD upon admission when not requiring oxygen therapy	Jun/10/2020
Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 virus RdRpol Small molecule In silico	in silico	3.24	Predicted to bind the SARS-CoV-2 RNA-dependent RNA polymerase active site.	Aug/18/2020

AI-suggested references

Link	Publication date
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease	Jun/15/2020
Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)	Jan/22/2022
Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach	Aug/14/2021
Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 virus	Mar/03/2022
Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein	Oct/08/2021
Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi-Organ Failure.	Nov/10/2020
Depinar, a drug that potentially inhibits the binding and entry of COVID-19 into host cells based on computer-aided studies.	May/12/2021

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT04407572	Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women	Completed		Apr/20/2020	Jun/14/2020
Alternative id - zinc-dvit-covid19 Interventions - Other: Serum zinc, vitamin d vitamin b12 levels . Study type - Observational Study results - No Results Available Locations - Pinar Yalcin Bahat, Istanbul, İ̇stanbul, Turkey Study designs - Observational Model: Case-Control\|Time Perspective: Prospective Enrollment - 44 Age - 18 Years to 45 Years (Adult) Outcome measures - Serum zinc, vitamin d vitamin b12 deficiency levels
NCT04395768	International ALLIANCE Study of Therapies to Prevent Progression of COVID-19	Recruiting	Phase 2	Sep/09/2020	Dec/31/2021
Alternative id - Alliance-COVID19 Interventions - Dietary Supplement: Vitamin C\|Drug: Hydroxychloroquine\|Drug: Azithromycin\|Dietary Supplement: Zinc Citrate\|Dietary Supplement: Vitamin D3\|Dietary Supplement: Vitamin B12 Study type - Interventional Study results - No Results Available Locations - National Institute of Integrative Medicine, Melbourne, Victoria, Australia Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: Double (Investigator, Outcomes Assessor)\|Primary Purpose: Treatment Enrollment - 200 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Symptoms\|Length of hospital stay\|invasive mechanical ventilation or mortality\|Mortality\|mechanical ventilation\|oxygen\|ICU\|days in hospital\|days in ICU\|renal replacement therapy\|Extracorporeal support

Export (.csv)