Other substances

VHH-72-VHH-72

An anti-Spike (SARS-CoV-2) nanobody construct.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

VHH-72-VHH-72 is a bivalent nanobody with a (GGGGS)3 linker joining two VHH-72 monomers. The monomeric form was found to recognize SARS-CoV Spike protein. It was isolated using phage display technique and originated in a SARS-CoV-immunized llama. The bivalent nanobody also recognizes SARS-CoV-2 Spike protein and neutralizes the corresponding pseudovirus in vitro (Wrapp et al., 2020).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
Spike protein Biophysical assay In vitro Antibody 		in vitro biophysical assay; Huh7.5 cells cells 38.64

The nanobody bound to SARS-CoV-2 Spike protein and neutralized the corresponding pseudotyped virus in vitro.

 May/05/2020
Export (.csv)