Other substances

Valaciclovir

An acyclovir analogue and viral DNA polymerase inhibitor.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Valacyclovir is an acyclovil prodrug and analogue. Acyclovir itself is converted to the nucleotide analogue acyclovir triphosphate by viral thymidine kinase and several cellular enzymes. In this way it competitively inhibits viral DNA replication. Valacyclovir is used for treatment of genital herpes (NCIt).

Valaciclovir on DrugBank
Valaciclovir on PubChem
Valaciclovir on Wikipedia

Synonyms

Valacyclovir

Marketed as

BAGOVIR; CYCLOVAL; MITANGA; OVALAC; PERVIORAL; REVIRA; VACYLESS; VADIRAL; VALDACIR; VALOTIX; VALVIR; VALZTREX; VIRAMIXAL; VIROPEL; VOCIFLON; ZELITREX; ZELIVIRE; CO VALACYCLOVIR; VALACYCLOVIR; VALTREX

 

Structure image - Valaciclovir

CC(C)[C@@H](C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N

Supporting references

Link Tested on Impact factor Notes Publication date
Screening of Therapeutic Agents for COVID-19 Using Machine Learning and Ensemble Docking Studies
Screening 		in silico 6.71

Predicted to bind the SARS-CoV-2 spike protein or spike protein:ACE2 interface.

 Aug/05/2020

AI-suggested references

Link Publication date
Antiviral drugs suppress infection of 2019-nCoV spike pseudotyped virus by interacting with ACE2 protein
Apr/01/2022
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