Other substances

Vacuolin-1

A PIKfyve kinase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Vacuolin-1 on PubChem

 

Structure image - Vacuolin-1

C1COCCN1C2=NC(=NC(=N2)N/N=C/C3=CC(=CC=C3)I)N(C4=CC=CC=C4)C5=CC=CC=C5

Supporting references

Link Tested on Impact factor Notes Publication date
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Small molecule In vitro 		SVG-A cells; VERO E6 cells; SARS-CoV-2 strain 2019-nCoV/USA-WA1/2020 9.41

Inhibits SARS-CoV-2 release into cell from endosomes in an in vitro model (SVG-A cells), likely through PIKfyve kinase inhibition and consequent cathepsin maturation impairment.

 Aug/06/2020
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