Other substances

U18666A

A Niemann-Pick C1 inhibitor

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

U18666A is a Niemann-Pick C1 inhibitor (Zang et al., 2020).

U18666A on PubChem

Synonyms

U 18666A; 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride

 

Structure image - U18666A

CCN(CC)CCO[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CCC4=O)C)C.Cl

Supporting references

Link Tested on Impact factor Notes Publication date
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Small molecule In vitro 		Vero E6 cells; HEK293 cells; HEK293-hACE2 cells; MA104 cells; primary human intestinal epithelial cells; cardiomyocytes 9.41

Reduced chimeric SARS-CoV-2 virus titer in vitro. It also experimentally reduced S-protein-mediated cell-to-cell fusion.

 Nov/25/2020

AI-suggested references

Link Publication date
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry.
May/27/2021
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