Other substances

Tylophorine

A heterocyclic alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Tylophorine is an organonitrogen heterocyclic compound (ChEBI) with anti-cancer properties (Yang et al., 2013). It possesses in vitro anti-SARS-CoV-2 activity (Yang et al., 2020).

Tylophorine on PubChem

Synonyms

PI09

 

Structure image - Tylophorine

COC1=C(C=C2C(=C1)C3=C(CN4CCC[C@H]4C3)C5=CC(=C(C=C52)OC)OC)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
Small molecule In vitro 		Vero E6 cells 4.23

Manifested in vitro anti-SARS-CoV-2 activity in Vero E6 cells with EC50 of 78 nM in a cytopathic effect assay and 76.8 nM in an immunofluorescence assay, with a selectivity index of 77 or 46.

 Dec/14/2020

AI-suggested references

Link Publication date
Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents
May/12/2020
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation
Mar/15/2022
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