Other substances

Trifluoperazine

A phenothiazine antipsychotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Trifluoperazine is a phenothiazine derivative, which acts as a dopamine antagonist and a calmodulin inhibitor. It is used for its antipsychotic and antiemetic properties (NCIt).

Trifluoperazine on DrugBank
Trifluoperazine on PubChem
Trifluoperazine on Wikipedia

Marketed as

ESKAZINE; ESKAZINYL; JATRONEURAL; MODALINA; STELAZINE; TERFLUZINE; TRIFLUOPERAZ; TRIFLUOPERAZINE (HYDROCHLORIDE); TRIFTAZIN

 

Structure image - Trifluoperazine

CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening 		Vero cells 5.09 Nov/25/2020
Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro
ACE2 Biophysical assay In vitro In silico 		in silico; in vitro biophysical assay; ACE2 high-expressing HEK293T cells; ACE2-HEK293T cell membrane chromatography 3.65

Bound to ACE2 and cell membranes of ACE2-expressing cells and reduced SARS-CoV-2 Spike pseudotyped virus entry ratio in vitro.

 Dec/10/2020

AI-suggested references

Link Publication date
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
Nov/04/2021
Screening for inhibitors against SARS-CoV-2 and its variants.
May/07/2022
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