Triamcinolone
A corticosteroid hormone receptor agonist.
General information
Triamcinolone is a synthetic glucocorticoid with immunomodulatory and anti-inflammatory activity. It activates glucocorticoid-responsive genes such as lipocortins, which prevents inflammation through inhibition of prostaglandin and leukotriene synthesis. Pro-inflammatory cytokine production (e. g. interleukin (IL)-1and IL-6) and the activation of cytotoxic T-lymphocytes is also inhibited. Triamcinolone also stimulates apoptosis (NCIt).
Triamcinolone on DrugBank
Triamcinolone on PubChem
Triamcinolone on Wikipedia
Marketed as
TRIAMCINONLONE ACETONIDE (also KENALOG; TRIDERM; ASACORT ALLERGY 24HOUR; TRIESENCE; ZILRETTA); ARISTOSPAN (TRIAMCINOLONE HEXACETONIDE)
C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
|
GES1 cells; M0 and M1 macrophages | 4.86 | Decreases IL-6 secretion in M1 macrophages in vitro. |
Jun/27/2020 |
