Tilorone
A small-molecule interferon inducer.
General information
Tilorone is a fluoren-9-one, which acts as an interferon inducer and a selective α7 nicotinic acetylcholine receptor agonist. Tilorone has anti-inflammatory, antineoplastic, and antiviral properties (ChEBI).
Tilorone on PubChem
Tilorone on Wikipedia
Marketed as
AMIXIN; LAVOMAX
CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening |
Vero cells | 5.09 | Nov/25/2020 | |
|
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Polysaccharide Small molecule In vitro |
ACE2-GFP HEK293T cells; Calu-3 cells; Vero E6 cells; SARS-CoV-2 pseudotyped particles | 6.26 | Raloxifene treatment combined with tilorone synergistically inhibited SARS-CoV-2 pseudovirus infection in Vero E6 cells. Treatment with tilorone alone resulted in modest virus-related cytopathic effect reduction. |
Nov/04/2020 |
|
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
Spike protein Small molecule In vitro |
Vero E6 cells; Vero 76 cells; Caco-2 cells; Calu-3 cells; A549-ACE2 cells; Huh-7 cells; human primary monocytes; SARS-CoV-2 strain USA_WA1/2020; (VSV) SARS-CoV-2 Spike-psudotyped virus | 2.87 | (Dihydrochloride salt.) SARS-CoV-2 live virus inhibition by the compound in vitro was cell line-dependent. The drug displayed the best efficacy in A549-ACE2 cells (IC50 of 180 nM). It bound Spike RBD, but it did not inhibit SARS-CoV-2 Spike-pseudotyped virus. |
Mar/10/2021 |
