Other substances

Tiapride

A benzamide dopamine receptor antagonist.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Tiapride is a selective benzamide D2 and D3 dopamine receptor antagonist active in the brain (DrugBank).

Tiapride on PubChem
Tiapride on Wikipedia

Marketed as

ITALPRID; SEREPRID; SEREPRILE; TIALAREAD; TIAPRID; TIAPRIDAL; TIAPRIDE; TIAPRIDEX; TIAPRIM; TIAPRIZAL; TIARYL

 

Structure image - Tiapride

CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro
ACE2 Biophysical assay In vitro In silico 		in silico; in vitro biophysical assay; ACE2 high-expressing HEK293T cells; ACE2-HEK293T cell membrane chromatography 3.65

Bound to ACE2 and cell membranes of ACE2-expressing cells and reduced SARS-CoV-2 Spike pseudotyped virus entry ratio in vitro.

 Dec/10/2020
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