Other substances

Thioridazine

A phenothiazine antipsychotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Thioridazine is a phenothiazine derivative that is used as an antipsychotic agent. It acts e. g. as a serotonergic antagonist, a H1-receptor antagonist, or an alpha-adrenergic antagonist (ChEBI). It has been withdrawn from most markets due to cardiac side effects (DrugBank).

Thioridazine on PubChem
Thioridazine on Wikipedia

Synonyms

Mellaril

Marketed as

THIORIDAZINE HYDROCHLORIDE

 

Structure image - Thioridazine

CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening 		Vero cells 5.09 Nov/25/2020
Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro
ACE2 Biophysical assay In vitro In silico 		in silico; in vitro biophysical assay; ACE2 high-expressing HEK293T cells; ACE2-HEK293T cell membrane chromatography 3.65

Bound to ACE2 and cell membranes of ACE2-expressing cells and reduced SARS-CoV-2 Spike pseudotyped virus entry ratio in vitro.

 Dec/10/2020

AI-suggested references

Link Publication date
Screening for inhibitors against SARS-CoV-2 and its variants.
May/07/2022
Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.
Aug/15/2020
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