Other substances

Thiamine

A water-soluble essential vitamin.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
7
 AI-suggested references
2
 Clinical trials

General information

Thiamine on PubChem

Synonyms

Thiamin; Vitamin B1

Marketed as

BETALIN S; BIAMINE; THIAMINE; THIAMINE HYDROCHLORIDE; VITAMIN B1

 

Structure image - Thiamine

CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO

Supporting references

Link Tested on Impact factor Notes Publication date
Dual Targeting of 3CLpro and PLpro of SARS-CoV-2: A Novel Structure-Based Design Approach to treat COVID-19
3CLpro RdRpol Small molecule In silico 		in silico

Predicted to bind both the SARS-CoV-2 RNA-dependent RNA polymerase and 3C-like protease.

 Dec/10/2020

AI-suggested references

Link Publication date
Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs.
Mar/31/2022
Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS CoV-2 based on Network Pharmacology and Molecular Docking analysis.
Dec/30/2020
Exploring Structural Mechanism of COVID-19 Treatment with Glutathione as a Potential Peptide Inhibitor to the Main Protease: Molecular Dynamics Simulation and MM/PBSA Free Energy Calculations Study
Oct/27/2020
The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19.
Apr/06/2021
Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study.
Jun/30/2021
Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile.
Mar/02/2021
Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi-Organ Failure.
Nov/10/2020

Clinical trials

ID Title Status Phase Start date Completion date
NCT04407572 Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women Completed Apr/20/2020 Jun/14/2020
  • Alternative id - zinc-dvit-covid19
  • Interventions - Other: Serum zinc, vitamin d vitamin b12 levels .
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Pinar Yalcin Bahat, Istanbul, İ̇stanbul, Turkey
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 44
  • Age - 18 Years to 45 Years   (Adult)
  • Outcome measures - Serum zinc, vitamin d vitamin b12 deficiency levels
NCT04395768 International ALLIANCE Study of Therapies to Prevent Progression of COVID-19 Recruiting Phase 2 Sep/09/2020 Dec/31/2021
  • Alternative id - Alliance-COVID19
  • Interventions - Dietary Supplement: Vitamin C|Drug: Hydroxychloroquine|Drug: Azithromycin|Dietary Supplement: Zinc Citrate|Dietary Supplement: Vitamin D3|Dietary Supplement: Vitamin B12
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - National Institute of Integrative Medicine, Melbourne, Victoria, Australia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Symptoms|Length of hospital stay|invasive mechanical ventilation or mortality|Mortality|mechanical ventilation|oxygen|ICU|days in hospital|days in ICU|renal replacement therapy|Extracorporeal support
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