Other substances

Theaflavin

A flavonoid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Theaflavin is a natural flavonoid compound with strong antioxidant properties (NCIt).

Theaflavin on PubChem
Theaflavin on Wikipedia

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro 3CLpro Small molecule Enzyme assay In vitro	in vitro enzyme assay; HEK293T (cytotoxicity)	1.81	Inhibited the SARS-CoV-2 3C-like protease in vitro at non-cytotoxic levels.	Sep/17/2020
Druggability for COVID-19: in silico discovery of potential drug compounds against nucleocapsid (N) protein of SARS-CoV-2 Nucleocapsid protein Small molecule In silico	in silico		Predicted to bind the SARS-CoV-2 nucleocapsid (N) protein.	Dec/09/2020

AI-suggested references

Link	Publication date
Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Polymerase Active-site with Better Docking Results than Remdesivir.	Sep/13/2021
Repurposing of anticancer phytochemicals for identifying potential fusion inhibitor for SARS-CoV-2 using molecular docking and molecular dynamics (MD) simulations.	Mar/22/2021
Molecular Docking and Dynamics Simulation of Natural Phenolic Compounds with GSK-3beta: A Putative Target to Combat Mortality in Patients with COVID-19.	Aug/03/2022
Elucidation of the inhibitory activity of plant-derived SARS-CoV inhibitors and their potential as SARS-CoV-2 inhibitors.	Jun/14/2021
Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2.	Dec/01/2021
Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study	Aug/07/2020
Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID-19	Aug/15/2021
Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors	Nov/05/2021
Virtual screenings of the bioactive constituents of tea, prickly chaff, catechu, lemon, black pepper, and synthetic compounds with the main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE 2) of SARS-CoV-2.	Jun/15/2021
GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies	Oct/10/2020
The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase	Mar/18/2020
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis	Jul/28/2020
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.	Aug/05/2021
Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study	May/11/2020
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins	Apr/20/2022
Molecular Docking Studies to Identify Promising Natural Inhibitors Targeting SARS-CoV-2 Nsp10-Nsp16 Protein Complex	Feb/28/2022
Topological indices and QSPR/QSAR analysis of some antiviral drugs being investigated for the treatment of COVID-19 patients.	Dec/31/2020
Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2	Apr/17/2020
Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro.	Oct/08/2021
Inhibition of ACE2 Expression by Ascorbic Acid Alone and its Combinations with Other Natural Compounds	May/10/2021
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach	Aug/21/2020
Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins.	Jun/11/2021
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants	Jan/21/2022
Effects of theaflavin-gallate in-silico binding with different proteins of SARS-CoV-2 and host inflammation and vasoregulations referring an experimental rat-lung injury.	Feb/08/2022
Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions	Jun/17/2021
In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors.	Jun/03/2021
Distance based and bond additive topological indices of certain repurposed antiviral drug compounds tested for treating COVID-19.	Feb/20/2021
In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity.	Mar/18/2021

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