Other substances

Theaflavin gallate

A flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

2
 Supporting references
0
 Contradictory references
5
 AI-suggested references
0
 Clinical trials

General information

Theaflavin gallate on PubChem

Synonyms

Theaflavin-3'-O-gallate; TF2a; Theaflavin 3-gallate

 

Structure image - Theaflavin gallate

C1CC(=O)C2=C(CC1[C@@H]3[C@@H](CC4=C(C=C(C=C4O3)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)C(=CC(=C2O)O)[C@@H]6[C@@H](CC7=C(C=C(C=C7O6)O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study
Spike protein Small molecule In silico 		in silico 1.90

Predicted to bind SARS-CoV-2 spike protein central channel (better than hydroxychloroquine).

 Aug/07/2020
Black tea bioactives as inhibitors of multiple targets of SARS-CoV-2 (3CLpro, PLpro and RdRp): a virtual screening and molecular dynamic simulation study
3CLpro PapainLpro RdRpol Small molecule In silico 		in silico 3.22

Predicted to inhibit SARS-CoV-2 Papain-like protease.

 Mar/10/2021

AI-suggested references

Link Publication date
Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Polymerase Active-site with Better Docking Results than Remdesivir.
Sep/13/2021
Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study
Aug/07/2020
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis
Jul/28/2020
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.
Aug/05/2021
Effects of theaflavin-gallate in-silico binding with different proteins of SARS-CoV-2 and host inflammation and vasoregulations referring an experimental rat-lung injury.
Feb/08/2022
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