Temsirolimus
A mammalian target of rapamycin inhibitor.
General information
Temsirolimus is a mammalian target of rapamycin (mTOR) inhibitor. It arrests the cell cycle progression in C1 phase and is used in the treatment of cancer. Temsirolimus was suggested to inhibit SARS-CoV-2 infection via mTOR inhibition (although by an unknown mechanism) (Mullen et al., 2021; NCIt).
Temsirolimus on DrugBank
Temsirolimus on PubChem
Temsirolimus on Wikipedia
Marketed as
TORISEL; TEMSIROLIMUS
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Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States
Preprint |
in silico | one of the top drugs and compounds identified by ViroTreat |
May/17/2020 | |
|
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening |
Vero cells | 5.09 | Nov/25/2020 | |
|
Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2
Preprint |
human renal cortical epithelial cells | Apr/23/2020 | ||
|
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Small molecule In vitro |
Vero cells; human lung air-liquid interface cultures; SARS-CoV-2 isolate USA-WA1/2020 | 12.12 | Inhibited SARS-CoV-2 replication in Vero cells, possibly through mTORC1 inhibition. |
Mar/25/2021 |
