Other substances

Taxifolin

A flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Taxifolin is a natural flavonoid from the polyphenols class. It can be found in various conifers, fruit, vegetables, wine, tea and cocoa. It is a potential chemoprotective agent. Taxifolin showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders.

Regarding SARS-CoV-2, our AIM tool found the data that taxifolin could help against SARS-CoV-2 by inhibiting its protease.

Taxifolin on DrugBank
(-)-Taxifolin on PubChem
(+)-Taxifolin on PubChem
Taxifolin on Wikipedia

Synonyms

(-)-Taxifolin (enantiomer); (+)-Taxifolin (enantiomer); dihydroquercetin

C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds Preprint	in silico		(-)-Taxifolin enantiomer. Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds	Mar/03/2020
Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease 3CLpro Small molecule In silico	in silico	2.01	(+)-Taxifolin is predicted to inhibit the SARS-CoV-2 3C-like protease.	Nov/25/2020

AI-suggested references

Link	Publication date
In silico screening of phytopolyphenolics for the identification of bioactive compounds as novel protease inhibitors effective against SARS-CoV-2.	Jun/03/2020
Potential Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 606 Million Compounds	Apr/12/2021
Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential phytochemicals to combat SARS-CoV-2.	Apr/19/2021
Flavonoid compounds of buah merah (Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approach	Aug/10/2021
Bioavailability and Safety of Dihydroquercetin (Review)	Jan/01/2022
Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2	Oct/29/2021
Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E.	Apr/12/2022

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT04871802	Effect of the Dietary Supplement Taxifolin Aqua on the Recovery Period After COVID-19 Pneumonia	Not yet recruiting	Not Applicable	May/10/2021	Oct/01/2021
Alternative id - COVID-AQUA-1 Interventions - Dietary Supplement: Taxifolin Aqua Study type - Interventional Study results - No Results Available Locations - Russian Clinical Research Center for Gerontology, Moscow, Russian Federation Study designs - Allocation: Non-Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Supportive Care Enrollment - 100 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Dynamics of spirometry indices\|Dynamics of ECHO CG\|Dynamics of pulse wave velocity\|Dynamics of augmentation index\|Dynamics of biological age

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