Tannic acid

A polyphenolic compound.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

Tannic acid is a natural polyphenolic compound used as a remedy for various skin and mucosal conditions (DrugBank).

Tannic acid on PubChem
Tannic acid on Wikipedia

Gallotannin; Glycerite; Gallotannic acid; Digallic acid; Quercotannic acid

Link	Tested on	Impact factor	Notes	Publication date
The Inhibitory Effects of Plant Derivate Polyphenols on the Main Protease of SARS Coronavirus 2 and Their Structure–Activity Relationship 3CLpro Small molecule Enzyme assay In vitro	in vitro enzyme assay	3.27	Inhibited SARS-CoV-2 3C-like protease with an IC50 of ca. 9 μM in vitro.	Mar/30/2021

Link	Publication date
Elucidation of the inhibitory activity of plant-derived SARS-CoV inhibitors and their potential as SARS-CoV-2 inhibitors.	Jun/14/2021
Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2.	Dec/01/2021
Inhibitory Effects and Surface Plasmon Resonance-Based Binding Affinities of Dietary Hydrolyzable Tannins and Their Gut Microbial Metabolites on SARS-CoV-2 Main Protease	Mar/30/2022
Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity	May/11/2022
The Inhibitory Effects of Plant Derivate Polyphenols on the Main Protease of SARS Coronavirus 2 and Their Structure-Activity Relationship	Mar/30/2021
Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay.	Mar/29/2021
The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction	Jul/12/2021