Taxifolin

A flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

2
Supporting references
0
Contradictory references
0
Clinical trials

General information

Taxifolin is a natural flavonoid from the polyphenols class. It can be found in various conifers, fruit, vegetables, wine, tea and cocoa. It is a potential chemoprotective agent. Taxifolin showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders.

Regarding SARS-CoV-2, our AIM tool found the data that taxifolin could help against SARS-CoV-2 by inhibiting its protease. 

Taxifolin on DrugBank
(-)-Taxifolin on PubChem
(+)-Taxifolin on PubChem
Taxifolin on Wikipedia


Synonyms

(-)-Taxifolin (enantiomer); (+)-Taxifolin (enantiomer); dihydroquercetin

Structure not available

C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O


Supporting references

Link Tested on Impact factor Notes Publication date DB entry date
Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease
small molecule in silico 3CLpro
in silico 2.01

(+)-Taxifolin is predicted to inhibit the SARS-CoV-2 3C-like protease.

Nov/25/2020 Dec/02/2020
Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds
preprint
in silico

(-)-Taxifolin enantiomer. Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds

Mar/03/2020 Mar/30/2020