Soybean Trypsin Inhibitor
A protease inhibitor.
Potential treatment - pre-clinical evidence
Soybean Trypsin Inhibitor is a serine protease inhibitor. It was observed to inhibit TMPRSS2 (Sun et al., 2021).
Trypsin inhibitor A; Kunitz-type trypsin inhibitor A; KTI3
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Small molecule Enzyme assay Peptide Animal model In vitro In silico
|in silico; in vitro enzyme assay; Calu-3 2B4 cells; hACE2-BALB/c mice; (VSV) SARS-CoV-2 Spike pseudovirus; SARS-CoV-2 live virus
Soybean Trypsin Inhibitor inhibited TMPRSS2 in vitro with an IC50 of ca. 121 nM. It inhibited pseudoviral entry in Calu-3 cells only modestly. The compound reduced viral replication in cell culture only modestly.