Other substances

Scutellaria baicalensis extract

A plant extract.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Scutellaria baicalensis extract is a 70% ethanol extract from a plant widely used in the Traditional Chinese Medicine formulations (Liu et al., 2021).

Synonyms

Baikal skullcap extract; Chinese skullcap extract

 

Supporting references

Link Tested on Impact factor Notes Publication date
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
Small molecule Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay; Vero cells; HEK293T cell lysates; SARS-CoV-2 isolate C-Tan-nCoV Wuhan strain 01 4.31

Inhibits SARS-CoV-2 3C-like protease in vitro with IC50 of 8.52 µg/ml and blocks SARS-CoV-2 replication with EC50 of 0.74 µg/ml in Vero cells. It acts both at pre- and post-entry stages.

 Jan/04/2021
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