Other substances

scFv-IL6R-Fc

An IL-6 receptor blocker.

Phase of research

Potential treatment - theoretical effect

How it helps

Other treatment

Drug status

Experimental

1
 Supporting references
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 Contradictory references
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 AI-suggested references
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 Clinical trials

General information

scFv-IL6R-Fc is an artificial single-chain variable fragment against IL-6 receptor. It was hypothesized to inhibit SARS-CoV-2-induced immune damage after MSC-delivery (Zhang et al., 2021).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection
IL-6 ACE2 Stem cells Protein factor In vitro Antibody 		ACE2 Lenti-X 293 cells; TF-1 cells; C57BL/6J mice (safety profile and fusion protein expression) 6.70

The fusion protein blocked IL-6 pathway in vitro. 

 Jun/11/2021
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