SΔC-Fer
A candidate COVID-19 protein subunit vaccine.
General information
SΔC-Fer is an experimental COVID-19 vaccine. It is based on SARS-CoV-2 Spike protein lacking the 70 amino-acid C-terminal fragment. The protein is multivalently displayed on Helicobacter pylori ferritin nanoparticles (Powell et al., 2021).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice
Biophysical assay Protein factor Animal model In vitro Mixed substance |
in vitro binding assay; in vitro biophysical assay; cryo-EM; BALB/c mice | 12.69 | The vaccine particles were properly folded and elicited a neutralizing antibody response in mice after a single immunization. The response was at least 2-fold stronger than the one in convalescent patient sera. A boosting dose further increased the antibody titres. |
Jan/05/2021 |
