Salvianolic acid C
A natural benzofuran.
General information
Salvianolic acid C is a Traditional Chninese Medicine hydrophobic compound, which blocks the formation of six-helix bundle core of SARS-CoV-2 Spike protein and thus inhibits SARS-CoV-2 infection in vitro (Yang et al., 2020).
Salvianolic acid C on PubChem
C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=C3C=C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)O)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Discovery and structural optimization of 3-O-β-chacotriosyl oleanane-type triterpenoids as potent entry inhibitors of SARS-CoV-2 virus infections
Spike protein Biophysical assay Small molecule In vitro |
in vitro binding assay; in vitro biophysical assay; Vero E6 cells; 293T-ACE2 cells; SARS-CoV-2 pseudovirus; SARS-CoV-2 strain wuhan-HU-1 | 5.57 | The compound inhibited SARS-CoV-2 pseudovirus infection in 293T-ACE2 cells with an IC50 of ca. 3.85 μM and an SI of >25.97. |
Feb/08/2021 |
|
Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein
Spike protein Biophysical assay Small molecule In vitro |
in vitro binding assay; in vitro biophysical assay; 293T/ACE2 cells; Vero E6 cells; SARS-CoV-2 pseudovirus; SARS-CoV-2 strain Wuhan-Hu-1 | 13.49 | In vitro, the compound inhibited structural changes in SARS-CoV-2 Spike protein which lead to viral membrane fusion upon cell binding by Spike RBD. It inhibited SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells with an IC50 of 3.85 μM and an SI of >26 and live virus infection in Vero E6 cells with an EC50 of 3.41 μM and an SI of >29. |
Oct/06/2020 |
