Salinomycin
A polyether ionophore antibiotic.
General information
Salinomycin is a diterpene glycoside used in veterinary medicine (DrugBank).
Salinomycin on PubChem
Salinomycin on Wikipedia
Synonyms
Salinomycin sodium
CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Antiviral options against SARS-CoV-2 infection
Preprint Screening |
VERO E6 cell cultures | synergistic effect in combination with the virus-directed drug nelfinavir |
May/12/2020 | |
|
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate
Preprint |
Calu-3 human airway epithelial cells | higher IC50 value in Calu-3 cells than VERO E6 cells |
May/12/2020 | |
|
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro
Small molecule In vitro |
Vero E6 cells; Vero E6-hTMPRSS2 cells; Calu-3 cells | 4.10 | Inhibited SARS-CoV-2 in cell culture with high selectivity (the ratio between IC50 and EC50). It also supressed SARS-CoV-2 expression at the protein level. |
Nov/25/2020 |
|
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Small molecule In vitro Screening |
Huh7.5 cells; Calu-3 cells; primary normal human bronchial epithelial cells; iPSC-derived AT2 cells; SARS-CoV-2 strain USA WA1/2020 | 8.11 | Inhibited SARS-CoV-2 replication in Huh7.5 cells and also in Calu-3 cells with an SI of >3. |
Mar/23/2021 |
|
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia.
Small molecule In vitro Mechanism |
in vitro fluorescence assay; Vero cells; HEK293 cells; Calu-3 cells; SARS-CoV-2 strain IC19/2020 | 42.78 | The drug was identified based on its ability to prevent SARS-CoV-2-induced syncytia formation. Salinomycin inhibited SARS-CoV-2 replication in Vero cells with an IC50 of 0.22 μM. It displayed antiviral activity also in Calu-3 cells. |
Apr/07/2021 |
