S-FL-opt/S1 recombinant protein
A candidate COVID-19 DNA/protein subunit vaccine.
General information
S-FL-opt/S1 recombinant protein is a candidate COVID-19 vaccine formulation comprised of codon-optimized DNA encoding SARS-CoV-2 Spike protein and SARS-CoV-2 Spike protein S1 subunit, a combination which elicits an enhanced antibody production by the activated antigen-specific B cells. It is adjuvanted with aluminium hydroxide (Li et al., 2021).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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A Novel DNA and Protein Combination COVID-19 Vaccine Formulation Provides Full Protection against SARS-CoV-2 in Rhesus Macaques
Animal model In vitro |
Vero cells; C57BL/6N mice; New Zealand white rabbits; rhesus macaques; SARS-CoV-2 strain BP16 | 5.78 | The immunogenic potential of the DNA portion of the vaccine itself was verified in mice. The combination of DNA and protein subunit vaccines was shown to be superior in eliciting an immune response in rabbits compared to DNA or protein subunit vaccination alone. The combined formulation induced Spike-specific IgGs, neutralizing antibodies, and T cell responses in non-human primates. The primates were protected from SARS-CoV-2 infection in a tracheal viral challenge, which was demonstrated by absence of detectable viral RNA and infection-associated lung tissue damage. |
Feb/08/2021 |
