Other substances

rlcv-miR-rL1-28-3p

A plant derived miRNA.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

rlcv-miR-rL1-28-3p is a ginger derived miRNA. It can be transported via exosome-like nanoparticles. The miRNA reduced SARS-CoV-2-induced cytopathic effect in vitro. It inhibits the expression of the Spike gene (Teng et al., 2021).

rlcv-miR-rL1-28-3p on miRBase

 

3'–GAGGAAAGUAUCGCCUUCUAG–5'

Supporting references

Link Tested on Impact factor Notes Publication date
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12
Spike protein RNA nsp13 nsp12 Cell-based therapy Animal model In vitro Mechanism Mixed substance Extracellular vesicles 		Vero E6 cells; C57BL/6 mice; SARS-CoV-2 strain USA-WA1/2020 11.45

Ginger-derived exosome-like nanoparticles carrying the miRNA reduced SARS-CoV-2-induced cytopathic effect in vitro. It inhibits the expression of the Spike gene. 

 May/10/2021
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