Rhein

An anthraquinone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

Rhein is a bioactive natural anthraquinone compound (DrugBank).

Rhein on PubChem
Rhein on Wikipedia

Monorhein; Rheic acid; Rhubarb Yellow

Link	Tested on	Impact factor	Notes	Publication date
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening ACE2 TCM Biophysical assay Small molecule In vitro Mixed substance In silico	in silico; in vitro biophysical assay	7.10	Bound to and inhibited ACE2 in vitro.	Oct/10/2020

Link	Publication date
Feasibility analysis and mechanism exploration of Rhei Radix et Rhizome-Schisandrae Sphenantherae Fructus (RS) against COVID-19.	May/19/2022
Plant-derived active compounds as a potential nucleocapsid protein inhibitor of SARS-CoV-2: an in-silico study.	May/09/2022
Screening of potential spike glycoprotein / ACE2 dual antagonists against COVID-19 in silico molecular docking	Dec/10/2021
Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences	Jul/01/2020
Regulation of m6A Methylation as a New Therapeutic Option against COVID-19	Nov/08/2021
Blocking key mutated hotspot residues in the RBD of the omicron variant (B.1.1.529) with medicinal compounds to disrupt the RBD-hACE2 complex using molecular screening and simulation approaches.	Mar/04/2022
Diacerein: A potential multi-target therapeutic drug for COVID-19	Jun/01/2020