Other substances

Retro-2.1

An experimental antimicrobial.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Retro-2.1 is a compound with antibacterial and antiviral properties. It cound act on retrograde vesicular transport (Holwerda et al., 2020; Stechmann et al., 2010).

Retro-2.1 on PubChem

Synonyms

CHEMBL3109593; (2R)-6-Fluoro-1-methyl-2-[5-(2-methyl-1,3-thiazol-4-yl)thiophen-2-yl]-3-phenyl-2H-quinazolin-4-one

 

Structure image - Retro-2.1

CC1=NC(=CS1)C2=CC=C(S2)[C@@H]3N(C4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of an Antiviral Compound from the Pandemic Response Box that Efficiently Inhibits SARS-CoV-2 Infection In Vitro
Small molecule In vitro 		Vero E6 cells; Calu-3 cells 4.15

Inhibited SARS-CoV-2 replication with high selectivity index in vitro. It was active in both Vero E6 and Calu-3 cell lines. The compound likely acts on a post-entry stage(s) of viral infection as the post-infection treatment provides more significant inhibitory effect.

 Nov/26/2020
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