Reserpine
An alkaloid anti-hypertensive agent.
General information
Reserpine is an alkaloid which acts as an adrenergic uptake inhibitor with antihypertensive effects (NCIt).
Reserpine on DrugBank
Reserpine on PubChem
Reserpine on Wikipedia
Marketed as
APOPLON; HISERPIA; NOVORESERPINE; RESERFIA; RESERPINE; SERPALAN; SERPANRAY; SERPASIL
CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2
3CLpro PapainLpro Small molecule Enzyme assay In vitro |
in vitro enzyme assay; Vero E6 cells | 4.92 | The compound inhibited the SARS-CoV-2 Papain-like protease in a dose-dependent manner in vitro. It protected Vero E6 cells from viral infection with EC50 of 6.6 μM and SI of >15.2. It was determined to be active only when applied at both the pre- and post-entry stages of infection. |
Feb/01/2021 |
AI-suggested references
| Link | Publication date |
|---|---|
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Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites.
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Dec/11/2020 |
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Deep learning identifies synergistic drug combinations for treating COVID-19
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Sep/17/2021 |
