Other substances

Rac5c

A Papain-like protease inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

2
 Supporting references
0
 Contradictory references
5
 AI-suggested references
0
 Clinical trials

General information

Rac5c is a Papain-like protease inhibitor (Klemm et al., 2020).

Rac5c on PubChem

Synonyms

5c; Chebi:156041; N-[(2-methoxypyridin-4-yl)methyl]-1-[1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide

 

Structure image - Rac5c

CC(C1=CC=CC2=CC=CC=C21)N3CCC(CC3)C(=O)NCC4=CC(=NC=C4)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
PapainLpro Small molecule Enzyme assay In vitro 		in vitro enzyme assay; Vero cells 9.96

Inhibited SARS-CoV-2 Papain-like protease in vitro with an IC50 of 0.81 μM. It also showed anti-SARS-CoV-2 activity in Vero cells.

 Aug/26/2020
In silico Exploration of Inhibitors for SARS-CoV-2's Papain-Like Protease
PapainLpro Small molecule In silico 		in silico 3.69

Computationally modelled to inhibit SARS-CoV-2 Papain-like protease.

 Feb/04/2021

AI-suggested references

Link Publication date
Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2.
Aug/11/2021
Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease.
Dec/27/2020
Experimental and computational study of naphthalimide derivatives: Synthesis, optical, nonlinear optical and antiviral properties.
Aug/19/2021
Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties.
Nov/04/2021
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
Apr/12/2022
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