Quinine

A quinidine alkaloid antimalarial.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

Quinine is a natural quinidine alkaloid traditionally used for malaria treatment with multiple mechanisms of action (NCIt).

Quinine on DrugBank
Quinine on PubChem
Quinine on Wikipedia

CINKONA; JASOQUIN; QSM; QUALAQUIN; QUININE - ODAN; QUININE SULFATE QUINLUP; QUTIL; SULQUIN

Link	Tested on	Impact factor	Notes	Publication date
Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation Small molecule In vitro	Vero E6 cells; SARS-CoV-2 IHUMI-3 strain	4.59	The antimalarial drug inhibited SARS-CoV-2 in vitro at IC50 and IC90 similar to the concentrations reached during oral antimalarial treatment.	Sep/08/2020
Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2 Small molecule In vitro	Vero B4 cells; Caco-2 cells; Calu-3 cells; TMPRSS2 and/or ACE2-expressing A549 cells	5.05	Exerts antiviral activity against SARS-CoV-2 as tested on TMPRSS2-positive human cancer cell lines. It displays lower toxicity compared to chloroquine or hydroxychloroquine. Depending on the cell line used, the observed IC50 was in the range of ca. 3.7 to 50 μM.	Apr/09/2021

Link	Publication date
Antimalarial Quinacrine and Chloroquine Lose Their Activity by Decreasing Cationic Amphiphilic Structure with a Slight Decrease in pH.	Nov/08/2021
In silico studies on structural inhibition of SARS-CoV-2 main protease Mpro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis	Oct/27/2021
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides	Oct/10/2021
In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2.	Jul/06/2021
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins	Apr/20/2022
An Ayurvedic Perspective along with in Silico Study of the Drugs for the Management of Sars-Cov-2.	Jul/21/2020
4-Aminoquinoline compounds from the Spanish flu to COVID-19	Dec/15/2020
Potential of Quinine Sulfate for COVID-19 Treatment and Its Safety Profile: Review	Jun/25/2020
Molecular dynamics simulations of quinine encapsulation into biodegradable nanoparticles: A possible new strategy against Sars-CoV-2.	Aug/04/2021
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues.	Jul/01/2021

ID	Title	Status	Phase	Start date	Completion date
NCT04553705	Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)	Recruiting	Phase 2\|Phase 3	Sep/20/2020	Dec/04/2020
Alternative id - TQ/Omega-3 on COVID-19\|DOI: 10.31219/osf.io/u56fc Interventions - Drug: Omega 3/Nigella Sativa Oil\|Drug: Omega 3/Nigella Sativa Oil/Indian Costus\|Drug: Omega 3/Nigella Sativa Oil/Quinine pills\|Drug: Omega 3/Nigella Sativa Oil/Anise seed capsule\|Drug: Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice\|Drug: Active Comparator Study type - Interventional Study results - No Results Available Locations - Maternity and Children hospital, Mecca, Makkah, Saudi Arabia Study designs - Allocation: Randomized\|Intervention Model: Sequential Assignment\|Masking: Double (Participant, Care Provider)\|Primary Purpose: Treatment Enrollment - 200 Age - 25 Years to 40 Years (Adult) Outcome measures - Clinical improvement\|Recovery rate from positive to negative swaps\|Fever to normal temperature in days\|Remission of lung inflammation in CT or X-ray\|Length of hospitalization\|(PCR levels) polymerase chain reaction assay levels\|Respiratory indexes\|C-reactive protein mg/L\|Serum Ferritin ng/ml\|Lactic acid dehydrogenase U/L\|leukocytes count μl\|Lipid profile [LDL, HDL, Total cholesterol ]\|total plasma antioxidant capacity