An acridine antiprotozoal.

Phase of research

Potential treatment - pre-clinical evidence

How it helps


Drug status

Used to treat other disease

Supporting references
Contradictory references
AI-suggested references
Clinical trials

General information

Quinacrine (or its dihydrochloride salt) is an acridine derivative with potential antineoplastic and antiparasitic properties. It has been used for the treatment of malaria and other protozoal infections and as an immunomodulatory agent (NCIt; LiverTox). It is also thought to exhibit antiviral effects through organellar acidification (Rojas et al., 2021).

Quinacrine on DrugBank
Quinacrine on PubChem
Quinacrine on Wikipedia

Marketed as



Structure image - Quinacrine


Supporting references

Link Tested on Impact factor Notes Publication date
Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids
human pluripotent stem cell-derived colonic organoids


Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro
Small molecule In vitro
Vero E6 cells; SARS-CoV-2 clinical isolate (Da An Gene Co. Ltd, Guangdong, China) 3.82

Inhibited SARS-CoV-2 viral cytotoxicity in Vero E6 cells with EC50 of ca. 1.9 µM (multiplicity of infection (MOI) 0.1) or ca. 0.6 (MOI 0.01). Inhibited SARS-CoV-2 viral replication in Vero E6 cells with IC50 of ca. 1.4 µM (MOI 0.1) or ca. 0.6 (MOI 0.01). The CC50 of the compound in VeroE6 cells, as assayed by MTT test, was ca. 6.5 µM.

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
Spike protein Small molecule In vitro
Vero E6 cells; Vero 76 cells; Caco-2 cells; Calu-3 cells; A549-ACE2 cells; Huh-7 cells; human primary monocytes; SARS-CoV-2 strain USA_WA1/2020; (VSV) SARS-CoV-2 Spike-psudotyped virus 2.87

(Hydrochloride salt.) SARS-CoV-2 live virus inhibition by the compound in vitro was cell line-dependent. The drug displayed the best efficacy in A549-ACE2 cells (IC50 of 122 nM). It did not inhibit SARS-CoV-2 Spike-pseudotyped virus, however.


AI-suggested references