Other substances

Pyridone 6

A protein tyrosine kinase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Pyridone 6 is an ATP-competitive inhibitor of JAK1, 2, and 3 with anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells (Park et al., 2021).

Pyridone 6 on DrugBank
Pyridone 6 on PubChem

Synonyms

JAK inhibitor I; 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one; Merck-5

 

Structure image - Pyridone 6

CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O

Supporting references

Link Tested on Impact factor Notes Publication date
Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection
Small molecule In vitro 		Vero E6 cells; Calu-3 cells 3.47

Manifests anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells. The reason might be differential signalling and virus production in these cell lines.

 Jan/28/2021
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