Protoporphyrin IX
A tetrapyrrole metabolic precursor.
General information
Protoporphyrin IX is a tetrapyrrole metabolic precursor for hemes, cytochrome c, and chlorophyl (NCIt).
Protoporphyrin IX on DrugBank
Protoporphyrin IX on PubChem
Protoporphyrin IX on Wikipedia
CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C=C)C)C(=C4CCC(=O)O)C)C(=C3C)CCC(=O)O)C=C
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2
Biophysical assay Animal model In vitro |
In vitro biophysical assay; in vitro binding assay; Vero E6 cells; HEK293T cells; BALB/c mice; SARS-CoV-2 (S protein) pseudovirus; SARS-CoV-2 strain nCoV-SH01 (GenBank: MT121215.1) | 9.51 | Eliminates SARS-CoV-2 infection-induced cytopathic effect and N protein expression in Vero E6 cells at 1.25 μM. The compound was estimated to have EC50 of 0.23 μM and selectivity index of 952.74 (1.35 μM and 224.61 for <a href= |
Dec/09/2020 |
