Other substances

Prostratin

A natural protein kinase C agonist.

Phase of research

Potential treatment - theoretical effect

How it helps

Other treatment

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Prostratine is a natural diterpene that can be produced synthetically, as well. It displays HIV inhibitory activity. Prostatin has been proposed to activate protein kinase C and NF-κB signalling (Wender et al., 2008).

Prostratin on PubChem
Prostratin on Wikipedia

 

Structure image - Prostratin

C[C@@H]1C[C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)OC(=O)C

Supporting references

Link Tested on Impact factor Notes Publication date
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
in silico 4.86

In silico screening of potential ACE2 agonists. Theoretical amelioration of ACE2 depletion by virus attachment.

 Jun/27/2020
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