Other substances

Procyanidin

A flavonoid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Procyanidin on PubChem
Procyanidin on Wikipedia

Synonyms

Proanthocyanidin; Epicatechin-(4α→8)-epicatechin

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC4(C(C(C5=C(C=C(C=C5O4)O)O)O)O)C6=CC(=C(C=C6)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approach Spike protein 3CLpro ACE2 In silico	in silico	3.22	Predicted to interact with the SARS-CoV-2 spike protein and 3C-like protease and the host's ACE2 receptor.	Sep/22/2020
Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2 3CLpro PapainLpro Small molecule Enzyme assay In vitro	in vitro enzyme assay; Vero E6 cells	4.92	The compound inhibited the SARS-CoV-2 Papain-like protease in a dose-dependent manner in vitro. It protected Vero E6 cells from viral infection with EC50 of 2.5 μM and SI of >40. It was determined to be active at the pre-entry stage of infection.	Feb/01/2021

AI-suggested references

Link	Publication date
Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes.	Apr/20/2022
Molecular Docking and Dynamics Simulation of Natural Phenolic Compounds with GSK-3beta: A Putative Target to Combat Mortality in Patients with COVID-19.	Aug/03/2022
Phenylbenzopyrone of Flavonoids as a Potential Scaffold to Prevent SARSCoV-2 Replication by Inhibiting its MPRO Main Protease.	Jan/29/2021
Transcription factor NF-kappaB as target for SARS-CoV-2 drug discovery efforts using inflammation-based QSAR screening model.	Jun/23/2021
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study	Jul/29/2021
Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies.	Oct/29/2020
Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants.	Sep/12/2020
Pelargonium Extract EPs 7630 in the Treatment of Human Corona Virus-Associated Acute Respiratory Tract Infections - A Secondary Subgroup-Analysis of an Open-Label, Uncontrolled Clinical Trial.	Apr/30/2021
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2	Nov/30/2020
Therapeutic potential of phytoconstituents of edible fruits in combating emerging viral infections	Jul/08/2021
Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19	Oct/16/2020
Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's Claw) against the Main Protease 3CLpro of SARS-CoV-2 by Molecular Modeling	Feb/14/2022
Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis	Jun/09/2021

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