Other substances

Pitavastatin

A statin.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Pitavastatin is used for treatment of hypercholesterolemia. It has antioxidant properties (ChEBI).

Pitavastatin on DrugBank
Pitavastatin on PubChem
Pitavastatin on Wikipedia

Marketed as

PITAVASTATIN CALCIUM; ZYPITAMAG (PITAVASTATIN MAGNESIUM); LIVALO (PITAVASTATIN CALCIUM)

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19	Patients	21.57	A retrospective cohort study of in-hospital statin use among COVID-19 patients. Lower risk of all-cause mortality. Lower use of invasive mechanical ventilation, ARDS prevalence and ICU admission. Possible due to inflammatory response amelioration. Dosage - daily equivalent dose of statin, median 20 mg. Endpoints - 28-day all-cause mortality; ICU admission; use of invasive mechanical ventilation; ARDS incidence. Sample size 10 patients (1,219 statins + 12,762 control).	Aug/04/2020
Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19 [version 1; peer review: 2 approved] RdRpol Small molecule In silico	in silico	2.64	Predicted to bind the active site of the SARS-CoV-2 RNA-dependent RNA polymerase.	Sep/23/2020

AI-suggested references

Link	Publication date
Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19	Apr/28/2021
Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesis	Apr/14/2022
Statins and the COVID-19 main protease: in silico evidence on direct interaction	Apr/25/2020

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT02344290	Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults	Active, not recruiting	Phase 3	Mar/26/2015	Mar/26/2023
Alternative id - A5332\|11960\|1U01HL123339-01\|1U01HL123336-01\|EU5332 Interventions - Drug: Pitavastatin\|Drug: Placebo Study type - Interventional Study results - No Results Available Locations - Alabama CRS, Birmingham, Alabama, United States\|University of Arizona CRS, Tucson, Arizona, United States\|University of Southern California CRS, Los Angeles, California, United States\|UCLA CARE Center CRS, Los Angeles, California, United States\|Mills Clinical Research CRS, Los Angeles, California, United States\|VA West Los Angeles Medical Center CRS, Los Angeles, California, United States\|Los Angeles LGBT Center CRS, Los Angeles, California, United States\|Eisenhower Health Center at Rimrock CRS, Palm Springs, California, United States\|Stanford AIDS Clinical Trials Unit CRS, Palo Alto, California, United States\|UCSD Antiviral Research Center CRS, San Diego, California, United States\|Ucsf Hiv/Aids Crs, San Francisco, California, United States\|Harbor-UCLA CRS, Torrance, California, United States\|University of Colorado Hospital CRS, Aurora, Colorado, United States\|Denver Public Health CRS, Denver, Colorado, United States\|Yale University CRS, New Haven, Connecticut, United States\|VA Connecticut Healthcare System CRS, West Haven, Connecticut, United States\|Whitman-Walker Health CRS, Washington, District of Columbia, United States\|Georgetown University CRS (GU CRS), Washington, District of Columbia, United States\|Capital Medical Associates, PC CRS, Washington, District of Columbia, United States\|Infectious Diseases Clinic, Washington DC Veterans Affairs Medical Center CRS, Washington, District of Columbia, United States\|Malcom Randall VA Medical Center CRS, Gainesville, Florida, United States\|AHF-The Kinder Medical Group CRS, Miami, Florida, United States\|The University of Miami AIDS Clinical Research Unit (ACRU) CRS, Miami, Florida, United States\|University of Miami Infectious Disease Research Unit at Jackson Memorial Hospital CRS, Miami, Florida, United States\|AHF - South Beach CRS, Miami, Florida, United States\|Orlando Immunology Center CRS, Orlando, Florida, United States\|Community AIDS Network/Comprehensive Care Clinic CRS, Sarasota, Florida, United States\|Florida Department of Health - Hillsborough County, Tampa, Florida, United States\|AIDS Research and Treatment Center of the Treasure Coast CRS, Vero Beach, Florida, United States\|The Ponce de Leon Center CRS, Atlanta, Georgia, United States\|Augusta University Research Institute, Inc. CRS, Augusta, Georgia, United States\|Northwestern University CRS, Chicago, Illinois, United States\|Rush University CRS, Chicago, Illinois, United States\|UIC Project WISH CRS, Chicago, Illinois, United States\|Indiana University Infectious Diseases Research CRS, Indianapolis, Indiana, United States\|Department of Internal Medicine, University of Iowa Hospitals & Clinics CRS, Iowa City, Iowa, United States\|Bluegrass Care Clinic/University of Kentucky Research Foundation CRS, Lexington, Kentucky, United States\|550 Clinic -University of Louisville CRS, Louisville, Kentucky, United States\|Tulane - Louisiana Community AIDS Research Program (T-LaCARP) CRS, New Orleans, Louisiana, United States\|Johns Hopkins University CRS, Baltimore, Maryland, United States\|Tufts Medical Center CRS, Boston, Massachusetts, United States\|Massachusetts General Hospital CRS (MGH CRS), Boston, Massachusetts, United States\|Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS, Boston, Massachusetts, United States\|Boston Medical Center CRS, Boston, Massachusetts, United States\|Baystate Infectious Diseases Clinical Research CRS, Springfield, Massachusetts, United States\|Henry Ford Hosp. CRS, Detroit, Michigan, United States\|St. John Newland Medical Associates CRS, Southfield, Michigan, United States\|Abbott Northwestern Hospital CRS, Minneapolis, Minnesota, United States\|University of Mississippi Medical Center CRS, Jackson, Mississippi, United States\|Washington University Therapeutics (WT) CRS, Saint Louis, Missouri, United States\|Specialty Care Center CRS, Omaha, Nebraska, United States\|Cooper Univ. Hosp. CRS, Camden, New Jersey, United States\|New Jersey Medical School Clinical Research Center CRS, Newark, New Jersey, United States\|James J Peters VA Medical Center CRS, Bronx, New York, United States\|Mount Sinai Beth Israel CRS, New York, New York, United States\|VA New York Harbor Healthcare System (NYHHS), NY Campus CRS, New York, New York, United States\|Weill Cornell Chelsea CRS, New York, New York, United States\|Mount Sinai Downtown CRS, New York, New York, United States\|Mount Sinai West Samuels CRS, New York, New York, United States\|Mount Sinai St. Luke's Morningside CRS, New York, New York, United States\|Infectious Disease Clinical and Translational Research Center (CTRC) CRS, New York, New York, United States\|Columbia P&S CRS, New York, New York, United States\|Weill Cornell Uptown CRS, New York, New York, United States\|University of Rochester Adult HIV Therapeutic Strategies Network CRS, Rochester, New York, United States\|Chapel Hill CRS, Chapel Hill, North Carolina, United States\|Duke University Medical Center CRS, Durham, North Carolina, United States\|Greensboro CRS, Greensboro, North Carolina, United States\|Wake Forest Baptist Medical Center CRS, Winston-Salem, North Carolina, United States\|Cincinnati Clinical Research Site, Cincinnati, Ohio, United States\|Case Clinical Research Site, Cleveland, Ohio, United States\|Ohio State University CRS, Columbus, Ohio, United States\|University of Toledo Medical Center CRS, Toledo, Ohio, United States\|Oklahoma State University Center for Health Sciences CRS, Tulsa, Oklahoma, United States\|Division of Infectious Diseases Clinical Research Center- Drexel University CRS, Philadelphia, Pennsylvania, United States\|Penn Therapeutics, CRS, Philadelphia, Pennsylvania, United States\|Center of Translational AIDS Research, Lewis Katz School of Medicine at Temple University CRS, Philadelphia, Pennsylvania, United States\|Positive Health Clinic CRS, Pittsburgh, Pennsylvania, United States\|University of Pittsburgh CRS, Pittsburgh, Pennsylvania, United States\|The Miriam Hospital Clinical Research Site (TMH CRS) CRS, Providence, Rhode Island, United States\|Medical University of South Carolina: Division of Infectious Diseases CRS, Charleston, South Carolina, United States\|Palmetto Health Clinical Trial Department CRS, Columbia, South Carolina, United States\|Vanderbilt Therapeutics (VT) CRS, Nashville, Tennessee, United States\|Trinity Health and Wellness Center CRS, Dallas, Texas, United States\|Dallas VA Medical Center CRS, Dallas, Texas, United States\|UT Southwestern HIV/ID Clinical Trials Unit CRS, Dallas, Texas, United States\|Houston AIDS Research Team CRS, Houston, Texas, United States\|Michael E. DeBakey VAMC REPRIEVE CRS, Houston, Texas, United States\|Inova Heart and Vascular Institute CRS, Falls Church, Virginia, United States\|Virginia Commonwealth University CRS, Richmond, Virginia, United States\|University of Washington AIDS CRS, Seattle, Washington, United States\|Medical College of Wisconsin, Inc. CRS, Milwaukee, Wisconsin, United States\|Gaborone CRS, Gaborone, South-East District, Botswana\|Tropical Medicine Foundation Dr. Heitor Vieira Dourado CRS, Manaus, Amazonas, Brazil\|School of Medicine, Federal University of Minas Gerais CRS, Belo Horizonte, Minas Gerais, Brazil\|HGNI HIV Family Care Clinic - HHFCC CRS, Nova Iguacu, Rio De Janeiro, Brazil\|Hospital Nossa Senhora da Conceicao CRS, Porto Alegre, Rio Grande Do Sul, Brazil\|Centro de Referencia e Treinamento DST/AIDS CRS, Sao Paulo, São Paulo, Brazil\|Projeto Praça Onze Pesquisa em Saúde CRS, Rio de Janeiro, Brazil\|Hospital Federal dos Servidores do Estado CRS, Rio de Janeiro, Brazil\|Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro, Brazil\|Instituto de Infectologia Emilio Ribas CRS, Sao Paulo, Brazil\|Centro de Pesquisas Clínicas IC-HCFMUSP CRS, Sao Paulo, Brazil\|Vancouver ID Research & Care Centre Society CRS, Vancouver, British Columbia, Canada\|Hamilton Health Sciences - Special Immunology Services Clinic CRS, Hamilton, Ontario, Canada\|Maple Leaf Research CRS, Toronto, Ontario, Canada\|Toronto General Hospital CRS, Toronto, Ontario, Canada\|Chronic Viral Illness Service CRS, Montreal, Quebec, Canada\|Centre hospitalier de l'Université Laval CRS, Quebec City, Quebec, Canada\|GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS, Port-au-Prince, Haiti\|Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS, Port-au-Prince, Haiti\|Byramjee Jeejeebhoy Medical College (BJMC) CRS, Pune, Maharashtra, India\|Chennai Antiviral Research and Treatment (CART) CRS, Chennai, Tamil Nadu, India\|Barranco CRS, Lima, Peru\|San Miguel CRS, Lima, Peru\|Puerto Rico AIDS Clinical Trials Unit CRS, San Juan, Puerto Rico\|Soweto ACTG CRS, Johannesburg, Gauteng, South Africa\|Wits Helen Joseph Hospital CRS (Wits HJH CRS), Johannesburg, Gauteng, South Africa\|Durban International Clinical Research Site CRS, Durban, Kwa Zulu Natal, South Africa\|University of Cape Town Lung Institute (UCTLI) CRS, Cape Town, Western Cape Province, South Africa\|Famcru Crs, Tygerberg, Western Cape Province, South Africa\|Hospital General Universitario de Alicante, Alicante, Spain\|Hospital Germans Trias i Pujol, Badalona, Spain\|Hospital Universitario Valle d'Hebron, Barcelona, Spain\|Hospital Clinic de Barcelona, Barcelona, Spain\|Hospital Universitario de Bellvitge, Barcelona, Spain\|Hospital Universitario de Basurto de Basurto, Bilbao, Spain\|Hospital General Universitario De Elche, Elche, Spain\|Hospital Gregorio Universitario Maranon, Madrid, Spain\|Hospital Universitario Ramon y Cajal, Madrid, Spain\|Hospital Universitario Clinico San Carlos, Madrid, Spain\|Hospital Universitario 12 de Octubre, Madrid, Spain\|Hospital Universitario La Paz, Madrid, Spain\|Hospital Universitario Virgen de la Victoria, Málaga, Spain\|Thai Red Cross AIDS Research Centre (TRC-ARC) CRS, Bangkok, Thailand\|Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai, Thailand\|Joint Clinical Research Centre (JCRC)/Kampala Clinical Research Site, Kampala, Uganda\|Milton Park CRS, Harare, Zimbabwe Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)\|Primary Purpose: Prevention Enrollment - 7770 Age - 40 Years to 75 Years (Adult, Older Adult) Outcome measures - Time to the first event of a composite of major cardiovascular events\|Time to the first of each individual component of the primary endpoint\|Time to death (all-cause mortality)\|Time to death (all-cause mortality) and/or major adverse cardiovascular events (MACE)\|Time to any (composite) or each (individual) of the following clinical diagnoses (including recurrent diagnoses as appropriate)\|Calculated fasting low-density lipoprotein (LDL) and non-high-density lipoprotein (HDL) cholesterol level\|Time to any of the following adverse events (including recurrent events as appropriate)\|Incidence of COVID-19\|Incidence of serious COVID-19\|For substudy: volume of NCP at study entry and change in NCP over 2 years\|For substudy: evidence of non-calcified coronary atherosclerotic plaque (NCP)\|For substudy: progression of NCP\|For substudy: number of high risk plaque features\|For substudy: changes in inflammatory markers

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