Other substances

Piperine

An alkaloid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Piperine on PubChem

Structure image - Piperine

C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
In silico investigation of spice molecules as potent inhibitor of SARS-CoV-2 Spike protein 3CLpro Small molecule In silico	in silico	3.22	Predicted to bind the SARS-CoV-2 spike protein RBD and the 3C-like protease.	Sep/17/2020

AI-suggested references

Link	Publication date
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.	Jan/19/2021
Curcumin and Piperine in COVID-19: A Promising Duo to the Rescue?	Mar/15/2022
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.	Nov/08/2021
Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study	Dec/22/2020
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides	Oct/10/2021
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor	Nov/12/2020
In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection	Dec/29/2020
Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials	Mar/16/2022
In silico study of some selective phytochemicals against a hypothetical SARS-CoV-2 spike RBD using molecular docking tools.	Aug/28/2021
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial.	May/28/2021
Semi-Synthesis of N-Aryl Amide Analogs of Piperine from Piper nigrum and Evaluation of Their Antitrypanosomal, Antimalarial, and Anti-SARS-CoV-2 Main Protease Activities	Apr/29/2022
Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor	May/24/2020
Evaluation of potency of the selected bioactive molecules from Indian medicinal plants with MPro of SARS-CoV-2 through in silico analysis.	May/21/2021
Ethnomedicines of Indian origin for combating COVID-19 infection by hampering the viral replication: using structure-based drug discovery approach	Jun/23/2020
An In-silico Screening Strategy to the Prediction of New Inhibitors of COVID-19 Mpro Protein	Feb/24/2022