Other substances

Peptide #2

An anti SARS-CoV-2 peptide.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Peptide #2 is a 36 amino acid long peptide derived from SARS-CoV-2 Spike protein HR2 domain. It inhibits SARS-CoV-2 pseudovirus activity, potentially at the level of viral entry, where the peptide could bind Spike and inhibit fusion betweent the viral particle and the host cell (Kandeel et al., 2021).

 

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Supporting references

Link Tested on Impact factor Notes Publication date
Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
Spike protein Peptide In vitro Mechanism In silico 		in silico; Calu-3 cells 3.47

Inhibited S-mediated cell-to-cell fusion and SARS-CoV-2 Spike-pseudotyped virus infection with IC50 of 1.49 µM in vitro.

 Jan/11/2021
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