Other substances

Pentamidine

A pneumocystis pneumonia therapeutical for HIV-infected patients.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Pentamidine is a synthetic antifungal and antiprotozoal drug. It was suggested to act via binding to the pathogen’s DNA (NCIt).

Pentamidine on DrugBank
Pentamidine on PubChem
Pentamidine on Wikipedia

Marketed as

NEBUPENT; PENTACARINAT; PENTACRINAT; PENTAM; PENTAMIDINE ISETHIONATE; PNEUMOPENT

 

Structure image - Pentamidine

C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N

Supporting references

Link Tested on Impact factor Notes Publication date
Structural Insights into the Binding Modes of Viral RNA-Dependent RNA Polymerases Using a Function-Site Interaction Fingerprint Method for RNA Virus Drug Discovery
RdRpol Small molecule In silico 		in silico 4.07

Predicted to inhibit the SARS-CoV-2 RNA-dependent RNA polymerase via subpocket 2 binding.

 Sep/18/2020
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Small molecule In vitro 		in vitro bacteria-based assay 3.82

Displayed inhibitory activity against the potential ion channel ORF3a of SARS-CoV-2 in a bacterial model assay.

 Mar/23/2021
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