Other substances

Pentagalloylglucose

A tannin.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

A tannin (phenolic compound) antioxidant with multiple biological activities (including anti-cancer, anti-viral, anti-microbial, or anti-inflammatory) obtained from various natural sources (Torres-León et al., 2017).

Pentagalloylglucose on PubChem
Pentagalloylglucose on Wikipedia

Synonyms

1,2,3,4,6-pentagalloylglucose; PGG

 

Structure image - Pentagalloylglucose

C1=C(C=C(C(=C1O)O)O)C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease
Small molecule Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay 2.99

Inhibits the SARS-CoV-2 3C-like protease with IC50 of ca. 3.66 μM in vitro. It was computationally predicted to bind the protease's active site.

 Jan/06/2021

AI-suggested references

Link Publication date
1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection
Mar/04/2021
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
May/12/2022
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