PDA@Exosome
A nanoparticle formulation.
General information
PDA@Exosome is a nanoparticle formulation derived from hACE2-expressing 293T cells. The nanoparticles contain polydopamine (with antioxidant properties), which has been coated by exosome membrane in the process of exocytosis. PDA@Exosome has been shown to be biocompatible, to bind SARS-CoV-2 Spike protein in vitro, and to reduce Spike-induced lung inflammation in an animal model (Ma et al., 2022).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV-2 Trapping and Antioxidant Therapy
Spike protein ACE2 Cell-based therapy Novel compound Biophysical assay Animal model In vitro Mechanism Mixed substance Extracellular vesicles |
In vitro; biophysical assay; BALB/c mice | 9.23 | The formulation was biocompatible. It displayed antioxidative properties and competitively bound SARS-CoV-2 Spike protein in vitro. In a murine model of Spike protein-induced lung inflammation, transtracheal injection of the formulation decreased inflammation and tissue damage. |
Jan/22/2022 |
