Other substances

PCI-27483

A phenylbenzimidazole.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

PCI-27483 is an experimental anti-cancer drug (DrugBank).

PCI-27483 on PubChem

 

Structure image - PCI-27483

C1=CC2=C(C=C1C(=N)N)NC(=N2)C3=CC(=CC(=C3O)C4=C(C=CC(=C4)S(=O)(=O)N)O)CC(=O)N[C@@H](CC(=O)O)C(=O)O


 

Supporting references

Link Tested on Impact factor Notes Publication date
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Small molecule Enzyme assay Peptide Animal model In vitro In silico 		in silico; in vitro enzyme assay; Calu-3 2B4 cells; hACE2-BALB/c mice; (VSV) SARS-CoV-2 Spike pseudovirus; SARS-CoV-2 live virus 11.86

PCI-27483 inhibited TMPRSS2 in vitro with an IC50 of ca. 1.41 μM. It inhibited pseudoviral entry in Calu-3 cells only modestly. The compound reduced viral replication in cell culture only modestly.

 Apr/12/2021
Export (.csv)