Other substances

P17

A SARS-CoV-2-neutralizing antibody.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

P17 is a SARS-CoV-2-specific Spike RBD-binding human monoclonal antibody identified using a solid-phase immunotube screening method (Yao et al., 2020). P17 binds to Spike protein trimers of B.1.1.7 without a reduction in affinity. Binding is significantly weakened in the case of B.1.351 Spike trimer, however. For a standard version of Spike protein, the antibody displayed cooperative binding with antibodies HB27, H014, and FC05 (Sun et al., 2021; Wang et al., 2020; Yao et al., 2020).

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection Spike protein Biophysical assay Animal model In vitro Antibody	in vitro biophysical assay; cryo-EM; 293T cells (cell-to-cell phusion assay); hACE2 mice	20.51	Potently neutralizes SARS-CoV-2 pseudovirus (sub nM IC50). Acts synergistically with H014. The antibody significantly reduces viral loads and inflammatory damage in murine respiratory tract in both prophylactic and therapeutic modes.	Dec/01/2020
Structure-based development of human antibody cocktails against SARS-CoV-2 Spike protein Biophysical assay Animal model In vitro Antibody	in vitro biophysical assay; 293T cells (cell-to-cell fusion assay); Vero cells; Huh7 cells; hACE2-mice; BALB/c mice	20.51	The antibody binds to the SARS-CoV-2 spike protein synergistically with FC05.	Dec/01/2020
Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms Spike protein Cryo-EM Biophysical assay In vitro Antibody	in vitro biophysical assay; cryo-EM	20.51	P17 bound to Spike protein trimers of B.1.1.7 without a reduction in affinity. Binding was significantly weakened in the case of B.1.351 Spike trimer, however. For a standard version of Spike protein, the antibody displayed cooperative binding with antibodies HB27, H014, and FC05.	Mar/29/2021

AI-suggested references

Link	Publication date
Viral 3CLpro as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides	Jan/29/2022

Export (.csv)