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NCT04370223
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Ozone Auto-hemotherapy for COVID-19 Pneumonia |
Not yet recruiting |
Phase 3 |
May/25/2020 |
Dec/25/2020 |
- Alternative id - COVID-19 Networking group
- Interventions - Biological: Ozone auto-hemotherapy
- Study type - Interventional
- Study results - No Results Available
- Locations - Hospital Universitari Dr Josep Trueta, Girona, Spain|Clinica Nuestra Señora del Rosario, Ibiza, Spain|Hospital Quirón Rey Juan Carlos I, Madrid, Spain|Hospital Universitario 12 de Octubre, Madrid, Spain|Hospital Universitario Infanta Leonor, Madrid, Spain|Hospital Universitario Príncipe de Asturias de Alcalá de Henares, Madrid, Spain|Fundació Althaia de Manresa, Manresa, Spain|Hospital Vithas Valencia Consuelo, Valencia, Spain|Hospital Clínico Universitario de Valladolid, Valladolid, Spain|Clinica Claro, Vigo, Spain
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
- Enrollment - 208
- Age - 18 Years to 90 Years (Adult, Older Adult)
- Outcome measures - Rate of patients achieving improvement in clinical condition at day 14 after recruitment|Mortality at day 28|Rate of patients achieving improvement in clinical condition at day 28 after recruitment|Rate of patients achieving improvement in clinical condition at day 7 after recruitment|Time to clinical improvement or hospital discharge|Number of ventilator-free days at 28 days|Hospital length of stay|Time to a 2-fold decrease in ferritin|Time to a 2-fold decrease in C-protein reactive|Time to a 2-fold decrease in Dimer-D|Time to a 2-fold decrease in Lactate Dehydrogenase|Time to a 2-fold decrease in Neutrophils to Lymphocytes ratio
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NCT04400006
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Ozone Therapy in the Prevention of COVID-19 Infection |
Completed |
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May/06/2020 |
May/17/2020 |
- Alternative id - 2761
- Interventions -
- Study type - Observational
- Study results - No Results Available
- Locations - Kardelen Gencer Atalay, Istanbul, Turkey
- Study designs - Observational Model: Case-Only|Time Perspective: Prospective
- Enrollment - 71
- Age - 18 Years to 90 Years (Adult, Older Adult)
- Outcome measures - The survey that was taken by telephone calls
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NCT04444531
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Ozone Therapy and Coronavirus Disease of 2019 (COVID-19) Pneumonia |
Completed |
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Mar/20/2020 |
May/26/2020 |
- Alternative id - COVID Networking group
- Interventions -
- Study type - Observational
- Study results - No Results Available
- Locations - Policlinic Ibiza Hospital, Ibiza, Spain
- Study designs - Observational Model: Cohort|Time Perspective: Prospective
- Enrollment - 18
- Age - Child, Adult, Older Adult
- Outcome measures - Time to clinical improvement|Rate of patients with Clinical improvement at day 14|Rate of patients with Clinical improvement at day 28|Time to a 2-fold decrease of C-protein reactive from baseline|Time to a 2-fold decrease of ferritin from baseline|Time to a 2-fold decrease of Lactate Dehydrogenase from baseline|Time to a 2-fold decrease of D-dimer from baseline
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NCT04359303
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Indirect Endovenous Systemic Ozone for New Coronavirus Disease (COVID19) in Non-intubated Patients |
Not yet recruiting |
Phase 3 |
Jul/01/2020 |
Dec/01/2020 |
- Alternative id - P.Inv. Ozono-COVID19 Ver.1.2
- Interventions - Other: Systemic indirect endovenous ozone therapy
- Study type - Interventional
- Study results - No Results Available
- Locations - SEOT, Valencia, Spain
- Study designs - Allocation: Randomized|Intervention Model: Crossover Assignment|Masking: Double (Participant, Investigator)|Primary Purpose: Treatment
- Enrollment - 50
- Age - 18 Years and older (Adult, Older Adult)
- Outcome measures - COVID19 clinical scale|Number of died patients|Oro/nasopharynx virus|Thorax imaging (0=none; 1=unilateral; 2=bilateral; 3=ground-glass opacification; 4=consolidation)|Days in hospital|Venous gas blood analysis
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NCT04388514
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Blood Ozonization in Patients With SARS-CoV-2 Respiratory Failure |
Recruiting |
Not Applicable |
Apr/08/2020 |
Oct/08/2020 |
- Alternative id - CIG: Z7C2CA5837
- Interventions - Procedure: Medical Ozone procedure
- Study type - Interventional
- Study results - No Results Available
- Locations - Dott. Amato De Monte, Udine, Italy
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Investigator)|Primary Purpose: Treatment
- Enrollment - 90
- Age - 18 Years to 99 Years (Adult, Older Adult)
- Outcome measures - Time of respiratory improvement and earlier weaning from oxygen support|The time of respiratory improvement and earlier weaning from oxygen support|Assessment of the length of hospitalization|Assessment of the length of Intensive Care Unit (ICU) stay|Improvment in chest imaging finding|Improvment in cytokine release syndrome
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NCT04789395
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Evaluation of Post-covid 19 Patients Who Receive Ozonetheraphy With Thorax CT |
Recruiting |
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Sep/02/2020 |
Dec/20/2021 |
- Alternative id - 08.092.r1.125
- Interventions -
- Study type - Observational
- Study results - No Results Available
- Locations - Gaziosmanpaşa TREH, Istanbul, Gaziosmanpaşa, Turkey
- Study designs - Observational Model: Cohort|Time Perspective: Prospective
- Enrollment - 25
- Age - 18 Years to 80 Years (Adult, Older Adult)
- Outcome measures - prevention of pulmonary fibrosis in covid 19 pneumonia patients with ozone therapy
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NCT04366089
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Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora |
Recruiting |
Phase 2 |
Mar/26/2020 |
Dec/31/2020 |
- Alternative id - 110/2020
- Interventions - Other: Oxygen-ozone therapy, probiotic supplementation and Standard of care|Dietary Supplement: SivoMixx (200 billion)|Drug: Azithromycin|Drug: hydroxychloroquine
- Study type - Interventional
- Study results - No Results Available
- Locations - Francesco Pugliese, Rome, RM, Italy
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Treatment
- Enrollment - 152
- Age - 18 Years and older (Adult, Older Adult)
- Outcome measures - Delta in the number of patients requiring orotracheal intubation despite treatment|Delta of crude mortality|Delta of length of stay for patients in hospital|delta in the value of interleukin (IL)-1|delta in the value of IL-6|delta in the value of IL-10|delta in the value of Tumor Necrosis Factor (TNF)-alpha|delta in the value of cluster of differentiation (CD)4+ CD38/ Human Leukocyte Antigen-DR isotype (HLA-DR)|delta in the value of CD8+ CD38/ HLA-DR|delta in the value of fecal calprotectin|delta in the value of lipopolysaccharide (LPS)|delta in the value of zonulin|delta in the value of alpha1-antitrypsin
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NCT05089305
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Ozone Plasma on Lung Function and Inflammatory Parameters in Pulmonary Sequelae Associated With Coronavirus 19 Infection |
Enrolling by invitation |
Phase 2 |
Sep/04/2021 |
Dec/21/2022 |
- Alternative id - CUCS-INTEC-OLFISA-001
- Interventions - Drug: Ozone plasma
- Study type - Interventional
- Study results - No Results Available
- Locations - Fernando Grover Paez, Guadalajara, Jalisco, Mexico|Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara, Guadalajara, Jalisco, Mexico
- Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
- Enrollment - 35
- Age - 25 Years to 80 Years (Adult, Older Adult)
- Outcome measures - Lung Function|Inflammatory parameters|Blood Biometrics|Oxygen saturation|Ferritin
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