Other substances

Oroxylin A

A flavone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Oroxylin A is a flavone with antineoplastic properties. It also inhibits nitric oxide synthase (ChEBI).

Oroxylin A on PubChem
Oroxylin A on Wikipedia

Synonyms

Oroxylin

 

Structure image - Oroxylin A

COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O

Supporting references

Link Tested on Impact factor Notes Publication date
Oroxylin A is a severe acute respiratory syndrome coronavirus 2‐spiked pseudotyped virus blocker obtained from Radix Scutellariae using angiotensin‐converting enzyme II/cell membrane chromatography
Spike protein ACE2 TCM Biophysical assay Small molecule In vitro In silico 		in silico; in vitro binding assay; in vitro biophysical assay; hACE2-HEK293T cells; SARS-CoV-2 pseudotyped virus 4.09

The compound inhibited SARS-CoV-2 Spike pseudotyped virus cell entry. It binds to ACE2 in vitro and inhibits LC3-mediated autophagy in human ACE2-expressing HEK293T cells.

 Feb/15/2021

AI-suggested references

Link Publication date
Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology.
Sep/24/2020
Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker obtained from Radix Scutellariae using angiotensin-converting enzyme II/cell membrane chromatography
Feb/15/2021
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